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Year : 2021  |  Volume : 31  |  Issue : 2  |  Page : 163--168

Relation between vitamin d level and cyclin-dependent kinase-1 gene expression in egyptian patients with lupus nephritis and their impact on disease activity

Eman M. A. Osman1, Salma Y Abu El Nazar1, Dalia A Maharem2, Dhargam M Al-Jebouri3, Iman S Naga4 
1 Department of Immunology and Allergy Medical Research Institute, Alexandria University, Alexandria, Egypt
2 Internal Medicine, Medical Research Institute, Alexandria University, Alexandria, Egypt
3 National Blood Transfusion Center, Iraq Ministry of Health, Baghdad, Iraq, Egypt
4 Microbiology, Medical Research Institute, Alexandria University, Alexandria, Egypt

Correspondence Address:
Dr. Dalia A Maharem
21 Rayad Street, El Fagr Tower, Zeizenia, Alexandria
Egypt

Introduction: Lupus nephritis (LN) is a common complication of systemic lupus erythematosus. Vitamin D and cycline-dependent kinase-1 (CDK1) have been implicated in its pathogenesis. The aim of this study was to determine the relation between vitamin D level and CDK-1 in lupus nephritis patients and their impact on disease activity. Patients and Methods: The current study was conducted on 50 LN patients and 20 control subjects from Egyptian population using ELISA to assess vitamin D level in serum and TaqMan assay for CDK1 gene expression. Results: Serum vitamin D level was significantly lower in LN patients and CDK-1 gene was down expressed in the majority of LN patients. A significant inverse correlation was found between vitamin D level and 24 h protein in urine, ANA, anti-dsDNA, CRP, with a significant positive correlation with renal biopsy indices, eGFR. There was a non-significant inverse correlation between vitamin D and CDK-1 (before RO-3306 addition) and a positive correlation after RO-3306. A significant positive correlation was found between CDK-1 gene expressions with urinary albumin/creatinine ratio. However, a significant positive correlation was found between CDK-1 (after RO-3306 addition) and proteinuria. While a significant positive correlation was found between CDK-1 expression (after RO-3306 addition) and ANA, a significant positive correlation was found between CDK-1 expression (before RO-3306 addition) and anti-dsDNA but CDK-1 is not associated with renal biopsy indices nor with activity indices of SLE. There was a positive correlation between CDK-1 gene expression and CRP before and after RO-3306 addition. Conclusions: Vitamin D deficiency acts as a risk factor for developing LN. CDK-1 may have an association with the diagnosis of LN but its association with the progression of staging of LN is still confusing

How to cite this article:
Osman EM, Abu El Nazar SY, Maharem DA, Al-Jebouri DM, Naga IS. Relation between vitamin d level and cyclin-dependent kinase-1 gene expression in egyptian patients with lupus nephritis and their impact on disease activity.Indian J Nephrol 2021;31:163-168

How to cite this URL:
Osman EM, Abu El Nazar SY, Maharem DA, Al-Jebouri DM, Naga IS. Relation between vitamin d level and cyclin-dependent kinase-1 gene expression in egyptian patients with lupus nephritis and their impact on disease activity. Indian J Nephrol [serial online] 2021 [cited 2021 Dec 2 ];31:163-168
Available from: https://www.indianjnephrol.org/article.asp?issn=0971-4065;year=2021;volume=31;issue=2;spage=163;epage=168;aulast=Osman;type=0