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Year : 2021  |  Volume : 31  |  Issue : 3  |  Page : 303--306

Association of acute interstitial nephritis with nivolumab in renal cell carcinoma: A case report

Befa Noto-Kadou-Kaza, Geoffroy Desbuissons, Corinne Bagnis Isnard 
 Department of Nephrology, Pitie-Salpetriere, 47-80 Boulevard de l'Hôpital, 75013, Paris, France

Correspondence Address:
Dr. Befa Noto-Kadou-Kaza
Department of Nephrology, Pitie-Salpetriere, 47-80 Boulevard de l'Hôpital, 75013, Paris
France

Recently, a number of innovative anticancer agents such us the programmed death 1 (PD-1) immune checkpoint inhibitors have been developed. Nevertheless, this type of immunotherapy may be associated with immune-related adverse events whose pathophysiology is considered similar to those found in autoimmune diseases such as nephritis. We report the case of a 71-year-old female with metastatic renal carcinoma who underwent nephrectomy. After three lines of other chemotherapies (VEGF and mTOR inhibitors), the patient was treated by nivolumab (3 mg/kg) for 4 months and developed acute kidney injury 16 weeks after initiating this immunotherapy. Kidney biopsy displayed a diffuse extensive interstitial inflammation associated with moderate interstitial edema. The discontinuation of nivolumab and the administration of prednisone (at 1 mg/kg and tapered over 3 months) was an effective treatment of the interstitial edema and led to the recovery of the kidney function.

How to cite this article:
Noto-Kadou-Kaza B, Desbuissons G, Isnard CB. Association of acute interstitial nephritis with nivolumab in renal cell carcinoma: A case report.Indian J Nephrol 2021;31:303-306

How to cite this URL:
Noto-Kadou-Kaza B, Desbuissons G, Isnard CB. Association of acute interstitial nephritis with nivolumab in renal cell carcinoma: A case report. Indian J Nephrol [serial online] 2021 [cited 2022 Jan 21 ];31:303-306
Available from: https://www.indianjnephrol.org/article.asp?issn=0971-4065;year=2021;volume=31;issue=3;spage=303;epage=306;aulast=Noto-Kadou-Kaza;type=0