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Year : 2021  |  Volume : 31  |  Issue : 6  |  Page : 583--586

MHC Class I related chain A (MICA) Antibodies - A potential cause of renal allograft rejection

Ajay Kumar Baranwal1, Sanjay Kumar Agarwal2, Narinder Mehra3 
1 Department of Transplant Immunology and Immunogenetics, All India Institute of Medical Sciences; Department of Pathology, Command Hospital, Pune, Maharashtra, India
2 Department of Nephrology, All India Institute of Medical Sciences, New Delhi, India
3 Department of Transplant Immunology and Immunogenetics, All India Institute of Medical Sciences, Pune, Maharashtra; National Chair, ICMR, New Delhi, India

Correspondence Address:
Dr. Narinder Mehra
National Chair and Former Dean, All India Institute of Medical Sciences, Ansari Nagar, New Delhi - 110 029
India

MHC class I related chain A (MICA) antibodies, especially those directed against the donor in absence of donor-specific anti-HLA antibodies have been reported to be possibly associated with renal allograft rejection in sensitized recipients. We are the first ones to present a case series of five patients who underwent primary live related donor renal transplantation in non-sensitized recipients either in the presence of donor-specific MICA antibodies (MICA-DSA) or developed de novo. Four of them presented characteristics of either accelerated, acute or chronic antibody-mediated rejection (AMR) attributable to the presence of MICA DSA. This case series emphasizes that AMR due to MICA-DSA is amenable to treatment with conventional regimens for treatment of AMR and there is a need for screening of MICA antibodies especially those directed against the donor on case to case basis.

How to cite this article:
Baranwal AK, Agarwal SK, Mehra N. MHC Class I related chain A (MICA) Antibodies - A potential cause of renal allograft rejection.Indian J Nephrol 2021;31:583-586

How to cite this URL:
Baranwal AK, Agarwal SK, Mehra N. MHC Class I related chain A (MICA) Antibodies - A potential cause of renal allograft rejection. Indian J Nephrol [serial online] 2021 [cited 2022 May 16 ];31:583-586
Available from: https://www.indianjnephrol.org/article.asp?issn=0971-4065;year=2021;volume=31;issue=6;spage=583;epage=586;aulast=Baranwal;type=0