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Year : 2022  |  Volume : 32  |  Issue : 4  |  Page : 348--358

Correlation of AKI with risk factors, ventilatory support, renal replacement therapy in a cohort of COVID-19 patients

Phanidhar Mogga1, Shreevidya Venkatraman2, Urjitha Rajagopalan1, Prashanth Rajagopalan1, Prabhu Radhan3, Kumaresan Maithrayie1, Sivaraj Padmanabhan2, Swamikannu Murugan2, Archana Nagarajan4, Chandrasekaran Venkataraman1, Milly Mathew1, Georgi Abraham5, Nancy Lesley6 
1 Department of Nephrology, MGM Healthcare, Chennai, Tamil Nadu, India
2 Department of Internal Medicine, MGM Healthcare, Chennai, Tamil Nadu, India
3 Department of Radiology, MGM Healthcare, Chennai, Tamil Nadu, India
4 Department of Microbiology, MGM Healthcare, Chennai, Tamil Nadu, India
5 Department of Nephrology; Department of Internal Medicine, MGM Healthcare, Chennai, Tamil Nadu, India
6 Department of Statistical Analysis, MGM Healthcare, Chennai, Tamil Nadu, India

Correspondence Address:
Georgi Abraham
MGM Healthcare, No 54, Nelson Manickam Road, Aminjikarai, Chennai - 600 029, Tamil Nadu
India

Introduction: There is a scarcity of information on the incidence and outcomes of acute kidney injury (AKI) in COVID-19 patients in India. Therefore, we analyzed the correlation of AKI risk factors, ventilatory support, and renal replacement therapy and compared the outcomes of first and second COVID-19 waves in this tertiary care center. Methods: We retrospectively analyzed the patients' medical records with a positive RT-PCR for COVID-19 between July 2020 and May 2021. We looked at the clinical outcomes of the first and second COVID-19 waves and documented the frequency, risk factors for AKI, and the relationship between AKI and in-hospital mortality. Univariate and multivariate binomial logistic regression yielded odds ratios for the risk variables of AKI. Risk differences and age-adjusted odds ratios, as well as 99.5% confidence intervals, were used to compare COVID-19 outcomes between the first and second waves. Results: Of the 1260 hospitalized patients with COVID-19, 86 (6.8%) presented with AKI and 8 (0.7%) patients required dialysis. The most common comorbidity was diabetes mellitus (55.2%), hypertension (42.1%), hypothyroidism (11.3%), and coronary artery disease (8.1%). A total of 229 (18.17%) patients were admitted to ICU, 574 (45.5%) received ventilation, and 26 (2.0%) required mechanical ventilation. The incidence of in-hospital death in the patients with AKI as per the stage from 1 to 3 was 9 (15.8%), 7 (35%), and 5 (55.6%), respectively. Compared to the first wave, the second wave cohort had a lower risk of AKI (adj OR: 0.426; CI: 0.232–0.782) and mortality (adj OR: 0.252; CI: 0.090–0.707). Conclusions: In our study, AKI prevalence was 6.8%, the need for ventilation was 45.5%, ECMO 0.2%, and the mortality rate 2.9%. Second wave of COVID-19 exhibits improved clinical outcomes compared to the first wave.

How to cite this article:
Mogga P, Venkatraman S, Rajagopalan U, Rajagopalan P, Radhan P, Maithrayie K, Padmanabhan S, Murugan S, Nagarajan A, Venkataraman C, Mathew M, Abraham G, Lesley N. Correlation of AKI with risk factors, ventilatory support, renal replacement therapy in a cohort of COVID-19 patients.Indian J Nephrol 2022;32:348-358

How to cite this URL:
Mogga P, Venkatraman S, Rajagopalan U, Rajagopalan P, Radhan P, Maithrayie K, Padmanabhan S, Murugan S, Nagarajan A, Venkataraman C, Mathew M, Abraham G, Lesley N. Correlation of AKI with risk factors, ventilatory support, renal replacement therapy in a cohort of COVID-19 patients. Indian J Nephrol [serial online] 2022 [cited 2022 Sep 25 ];32:348-358
Available from: https://www.indianjnephrol.org/article.asp?issn=0971-4065;year=2022;volume=32;issue=4;spage=348;epage=358;aulast=Mogga;type=0