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Letters to Editor
22 (
3
); 231-232
doi:
10.4103/0971-4065.98790

Collapsing glomerulopathy: The Indian scenario

Department of Pathology, University College of Medical Sciences, Dilshad Garden, Delhi, India

Address for correspondence: Dr. Kiran Preet Malhotra, Department of Pathology, University College of Medical Sciences, Delhi - 110 095, India. E-mail: drkiranpreetmalhotra@yahoo.co.in

Licence

This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Disclaimer:
This article was originally published by Medknow Publications & Media Pvt Ltd and was migrated to Scientific Scholar after the change of Publisher.

Sir,

We read with interest the case report by Naaz et al. describing the first case of collapsing glomerulopathy in an HIV positive patient in Kashmir.[1] This lesion is being increasingly diagnosed by nephropathologists at other centers in India, with increasing awareness of the morphologic changes.[24] With reference to the above, we would like to mention that collapsing glomerulopathy is the commonest renal lesion associated with HIV; however, it is not HIV alone that causes this pathomorphologic insult. This assortment of pathologic changes is also seen in association with a myriad of other illnesses, namely infections including cytomegalovirus, Hepatitis C virus, and pulmonary tuberculosis; autoimmune disorders such as Systemic Lupus and adult Still's disease; malignancies including multiple myeloma and myeloid leukemia and with the use of drugs including interferon and pamidronate.[5] An increasing number of cases are also being diagnosed post-renal transplantation.[4] Identification of the lesion should be an indication of severe renal injury regardless of the causative etiology. Consciousness of this entity will enhance its diagnosis in the near future.

References

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  3. , , , , , , . Collapsing glomerulopathy occurring in HIV-negative patients with systemic lupus erythematosus: Report of three cases and brief review of the literature. Lupus. 2011;20:866-70.
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  4. , , , , . Collapsing glomerulopathy in renal allograft biopsies: A study of nine cases. Indian J Nephrol. 2011;21:10-3.
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