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Year : 2021  |  Volume : 31  |  Issue : 3  |  Page : 307-310

Renal hypouricemia with exercise induced acute kidney injury-A case report

1 Department of Nephrology, AINU, Hyderabad, Telangana, India
2 Department of Anesthesiology, Axon Group, Hyderabad, Telangana, India

Correspondence Address:
Dr. Srikanth Gundlapalli
Consultant Nephrologist, Asian Institute of Nephrology and Urology, Erramanzil Colony, Somajiguda, Hyderabad - 500 082, Telangana
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijn.IJN_127_20

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Acute kidney injury after exercise is most commonly secondary to rhabdomyolysis. Non-rhabdomyolysis AKI is secondary to a limited number of disorders of which renal hypouricemia (RHUC) needs a special mention. It is relatively a rare genetic disorder and is reported in Japanese and Ashkenazi Jews. Humans have lost the ability to metabolize uric acid as the “uricase” gene is suppressed. Renal tubules handle uric acid and aid in maintaining serum concentrations in the soluble range. Uric acid excretion is increased in RHUC patients due to proximal tubular defects. This leads to the loss of antioxidant capabilities of the kidney, predisposing them to severe AKI following anaerobic exercise. We report a case of exercise-induced AKI secondary to renal hypouricemia.


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Indian Journal of Nephrology
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Online since 20th Sept '07